Compounds > N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Page last updated: 2024-09-05

N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide and tipifarnib

N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide has been researched along with tipifarnib in 1 studies

Compound Research Comparison

Studies
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Trials
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Recent Studies (post-2010)
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Studies
(tipifarnib)		Trials
(tipifarnib)		Recent Studies (post-2010) (tipifarnib)
9073099294

Protein Interaction Comparison

ProteinTaxonomyN-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide (IC50)tipifarnib (IC50)
Chain B, Protein farnesyltransferase beta subunitRattus norvegicus (Norway rat)0.0007
Cytochrome P450 3A4Homo sapiens (human)2.88
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaBos taurus (cattle)0.5503
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaHomo sapiens (human)2.2237
Protein farnesyltransferase subunit betaBos taurus (cattle)0.0006
Protein farnesyltransferase subunit betaHomo sapiens (human)0.0019
Geranylgeranyl transferase type-1 subunit betaHomo sapiens (human)10
Geranylgeranyl transferase type-1 subunit betaBos taurus (cattle)1.1
Protein farnesyltransferase alpha subunitPlasmodium falciparum (malaria parasite P. falciparum)0.017
CAAX farnesyltransferase subunit beta Plasmodium falciparum (malaria parasite P. falciparum)0.017

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

1 other study(ies) available for N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide and tipifarnib

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013